Judith Mueller is an epidemiologist, professor at the School of Advanced Studies in Public Health (EHESP) and researcher at the Institut Pasteur. She returns to the interest of the fourth dose (second booster), 18 months after the launch of the against the and following the seventh of the epidemic with and provides an update on the effectiveness of current vaccines against the variants .
The Conversation: The vaccines currently in use were designed from the initial strain of SARS-CoV-2 that emerged in Wuhan. At present, what is known about their effectiveness against Omicron variants?
Judith Muller: Immunological research has shown that the Omicron variants, and in particular BA.4 and BA.5, escape more, developed following vaccination. An identical phenomenon is observed for antibodies acquired following an infection.
This is a normal natural mechanism:depending on the antibodies they encounter, and more specifically the given antibodies protecting against this infection. Evolution at these selects structures less well recognized by antibodies, with the consequence of maintaining the capacity for infection in an immunized population – this is immune escape.
On the other hand, it is not “useful” for a virus liketo be more dangerous. This is consistent with the observation that, so far, successive variants have not significantly diminished protection against of Covid-19 provided by vaccination.
The question is therefore rather this: could we, in the future, because of these genetic adaptations, see the emergence of a variant against which vaccination no longer or little protected against severe forms? It would rather be an unfortunate coincidence – it cannot be ruled out, but it is unlikely.
TC: We must therefore not confuse protection against severe forms of Covid-19 with protection against infection…
JM: Indeed, these are two different things and it can be confusing. Protection against infection (often referred to as “symptomatic infection” in studies) declines quite quickly after vaccination against Omicron variants:
On the contrary, thein case of infection moves very little with time and variations. As a result, the overall protection against severe forms (which includes protection against infection) and has decreased only slightly since vaccination.
The only exceptions are older people and those affected by a weakening of their immune system: their vaccine protection decreases more rapidly. . These are not such rare cases in our society: genetic disposition, chronic disease or current treatment against cancer lead to such an immune deficiency.
TC: Why do we talk about the importance of booster doses?
JM: You have to be aware that this overall protection against severe forms – which I describe as good against Omicron and over time – is far from perfect, since it is around 60 to 70% after the initial regimen (without reminder). In other words, 6 out of 10 cases of Covid-19 with complications can be prevented by vaccination. But the other 4 episodes will occur nonetheless. This can make a lot of people at the same time in hospitals, as soon as there is a new increase in infections.
After, this protection increases to approximately 80%. This additional protection is all the more interesting the older you are (from the age of 50) and you are exposed to a high risk of infection (as during an epidemic wave).
It is now considered that the booster is part of the complete vaccination scheme to obtain good protection against severe forms. The same reasoning also applies to unvaccinated people who have been infected – a makes it more durable and more against variants.
TC: There have been discussions about whether to lower the age for this second recall. Why ?
JM: A second booster dose. This is particularly interesting for older people, in whom the risk of complications is higher. There is no precise threshold – this is why the recommendation of the fourth dose is currently inconsistent between countries.
An additional booster also greatly reduces your risk of being infected (and infecting others) for about three months. For elderly or immunocompromised people, this means optimizing their protection. For younger adults living or working near vulnerable people, this helps secure contact for a certain period.
A broader fourth dose campaign would be – this is my personal opinion – to be reserved for an exceptional situation: an epidemic wave with a more dangerous variant, in the face of which transmission must absolutely and quickly be reduced to avoid the worst.
TC: Who is concerned today by this fourth dose, or second booster?
JM:, it is recommended from the age of 60 and for immunocompromised people. The recommendation now also covers adolescents and adults under 60 with for a severe form ( , …), including pregnant women from the first trimester of .
The fourth dose is also recommended for people around vulnerable people.
As explained previously, the idea here is to close “the» of risk by being beyond 80% protection.
TC: In this context, at the end of June the European Medicines Agency (EMA) authorized an additional vaccine, that of the French laboratory Valneva. What is the benefit of this additional vaccine, which brings the number of vaccines available in France to six?
JM: This vaccine is based on technology similar to that used to produce most vaccines againstseasonal. This could eventually convince people who would still be reluctant to use vaccine technology to .
It is currently authorized in adults aged 18 to 50 only, as it has not yet been evaluated in older people. Given its technology and the data presented by the EMA, this vaccine should provide substantial protection. His than that of the Vaxzevria vaccine (from Astra Zeneca) or mRNA vaccines.
It remains to be assessed to what extent this vaccine protects against the Omicron variants, because thewere conducted on the Wuhan strain. And of course, it will be necessary to observe closely the protection against infection and severe forms.
Pharmacovigilance data will also be carefully scrutinized, because this is a recent vaccine for which we do not yet have information on a very large scale, unlike previous vaccines (mRNA, viral vector) which have been administered to millions of people for 18 months.
TC: Speaking of which, there have been no new side effects identified with RNA vaccines?
JM: No, nothing essentially new since last summer. This is not surprising, because the number of doses administered and the observation period were already very high last year at the same time.
thein young people within a week after vaccination has since been observed more accurately – these myo – or usually progress without complication or . Above all, we now know that it is Covid-19 that increases the risk of .
There are still some questions aboutreported by a good number of women after vaccination. To conclude on an effect of vaccination, it is of course necessary to compare in vaccinated women to that ofwomen not (yet) vaccinated, for example in a clinical trial or in an epidemiological study after large-scale use.
According to the EMA, the available data make it possible to rule out a link between vaccination and the absence of periods, but.
If they are transient, menstrual irregularities impact quality of life but do not represent a health or health problem. find it interesting that with the vaccination against Covid-19, this quality of life is receiving the attention of the health authorities. It may be further considered and evaluated in clinical trials.. However, I